دورية أكاديمية
Influence of Cordyceps militaris-fermented grain substrate extracts on alleviating food allergy in mice
| العنوان: | Influence of Cordyceps militaris-fermented grain substrate extracts on alleviating food allergy in mice |
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| المؤلفون: | Jia-Shan Liu, Rong-Yi Huang, Yu-Jyun Wei, Guo-Jane Tsai, Chung-Hsiung Huang |
| المصدر: | Heliyon, Vol 9, Iss 12, Pp e23315- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Allergic enteritis, Cordyceps militaris, Food allergy, Grain substrate, Gut microbiota, Solid-state fermentation, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Background: Cordyceps militaris is recognized as a tonic in traditional Chinese medicine, and there have been documented findings on the anti-allergic properties of its extract derived from the fruiting body. Due to the limited availability of wild C. militaris, a specialized grain substrate has been devised for the solid-state fermentation of its fruiting bodies. However, the fermented grain substrate is considered waste and usually used as feeds for animals. To achieve the sustainable development goals, C. militaris-fermented grain substrate (CFGS) was collected to prepare CFGS extracts. Further, the anti-allergic properties of these extracts were assessed with the aim of exploring novel applications. Methods: The water extract and ethanol extract of CFGS were prepared, and their potential in alleviating allergic enteritis was assessed in mice with food allergy. Assessment of immunomodulatory effects included the measurement of serum antibodies and splenic cytokines. Additionally, influence of extracts on gut microbiota composition was examined through sequencing analysis of 16S rRNA gene from freshly collected feces of the mice. Results: Daily administration of the water and ethanol extracts, at doses of 50 or 250 mg/kg body weight, demonstrated a notable alleviation of allergic diarrhea and enteritis. This was accompanied by a decrease in mast cell infiltration in the duodenum and a reduction in allergen-specific IgE production in the serum. Both extracts led to a significant decrease in IL-4 secretion. Conversely, there was an increase in IFN-γ, IL-10, and TGF-β secretion from splenocytes. Remarkably, allergic mice exhibited a distinct fecal microbiota profile compared to that of normal mice. Intriguingly, the administration of these extracts had varying effects on the fecal microbiota. Conclusion: Taken together, these findings collectively indicate the potential of CFGS extracts as promising candidates for functional foods. These extracts show promise in managing allergic enteritis and modulating gut microbiota. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023105238; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e23315 |
| URL الوصول: | https://doaj.org/article/4906d3fac95949f1bd0e960a177722c2 |
| رقم الأكسشن: | edsdoj.4906d3fac95949f1bd0e960a177722c2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e23315 |