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Dietary fat source affects metabolism of fatty acids in pigs as evaluated by altered expression of lipogenic genes in liver and adipose tissues

التفاصيل البيبلوغرافية
العنوان: Dietary fat source affects metabolism of fatty acids in pigs as evaluated by altered expression of lipogenic genes in liver and adipose tissues
المؤلفون: P. Duran-Montgé, P.K. Theil, C. Lauridsen, E. Esteve-Garcia
المصدر: Animal, Vol 3, Iss 4, Pp 535-542 (2009)
بيانات النشر: Elsevier, 2009.
سنة النشر: 2009
المجموعة: LCC:Animal culture
مصطلحات موضوعية: swine, lipids, transcriptomics, lipogenesis, Animal culture, SF1-1100
الوصف: Little is known about pig gene expressions related to dietary fatty acids (FAs) and most work have been conducted in rodents. The aim of this study was to investigate how dietary fats regulate fat metabolism of pigs in different tissues. Fifty-six crossbred gilts (62 ± 5.2 kg BW) were fed one of seven dietary treatments (eight animals per treatment): a semi-synthetic diet containing a very low level of fat (no fat (NF)) and six fat-supplemented diets (ca. 10%) based on barley and soybean meal. The supplemental fat sources were tallow (T), high-oleic sunflower oil (HOSF), sunflower oil (SFO), linseed oil (LO), blend (FB) (55% T, 35% SFO and 10% LO) and fish oil (FO) blend (40% FO and 60% LO). Pigs were slaughtered at 100 kg BW and autopsies from liver, adipose tissue and muscle semimembranousus were collected for qPCR. The messenger ribonucleic acid (mRNA) abundances of genes related to lipogenesis were modified due to dietary treatments in both liver (sterol regulatory element-binding protein-1 (SREBP-1), acetyl CoA carboxylase (ACACA) and stearoyl CoA desaturase (SCD)) and adipose tissue (fatty acid synthase (FASN), ACACA and SCD), but were not affected in semimembranousus muscle. In the liver, the mRNA abundances of genes encoding lipogenic enzymes were highest in pigs fed HOSF and lowest in pigs fed FO. In adipose tissue, the mRNA abundances were highest in pigs fed the NF diet and lowest in pigs fed T. The study demonstrated that dietary FAs stimulate lipogenic enzyme gene expression differently in liver, fat and muscles tissues.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1751-7311
17517311
Relation: http://www.sciencedirect.com/science/article/pii/S1751731108003686; https://doaj.org/toc/1751-7311
DOI: 10.1017/S1751731108003686
URL الوصول: https://doaj.org/article/de491a9d80a443639988a76134986c06
رقم الأكسشن: edsdoj.491a9d80a443639988a76134986c06
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17517311
DOI:10.1017/S1751731108003686