دورية أكاديمية
Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding
| العنوان: | Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding |
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| المؤلفون: | Renuka Harit, Sajal De, Piyoosh Kumar Singh, Deepika Kashyap, Manish Kumar, Dibakar Sahu, Chander Prakash Yadav, Mradul Mohan, Vineeta Singh, Ram Singh Tomar, Kailash C. Pandey, Kapil Vashisht |
| المصدر: | Human Genomics, Vol 18, Iss 1, Pp 1-6 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | EGLN1 gene, COVID-19, Hypoxia, rs479200, rs516651, Host genetic factors, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract The present study investigated two single nucleotide polymorphisms (SNPs)—rs479200 and rs516651 in the host EGLN1/PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 COVID-19 patients from the Indian population (March 2020 to June 2021) was enrolled. Notably, the frequency of C allele (0.664) was twofold higher than T allele (0.336) in severe COVID-19 patients. Here, we report a novel finding that the C allele of rs479200 in the EGLN1 gene imparts a high risk of severe COVID-19 (odds ratio—6.214 (1.84–20.99) p = 0.003; 9.421 (2.019–43.957) p = 0.004), in additive inheritance model (adjusted and unadjusted, respectively). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1479-7364 |
| Relation: | https://doaj.org/toc/1479-7364 |
| DOI: | 10.1186/s40246-024-00572-1 |
| URL الوصول: | https://doaj.org/article/493495c034124de0857bfccccc96cd6a |
| رقم الأكسشن: | edsdoj.493495c034124de0857bfccccc96cd6a |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14797364 |
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| DOI: | 10.1186/s40246-024-00572-1 |