دورية أكاديمية
Retrospective cumulative dietary risk assessment of craniofacial alterations by residues of pesticides
| العنوان: | Retrospective cumulative dietary risk assessment of craniofacial alterations by residues of pesticides |
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| المؤلفون: | European Food Safety Authority (EFSA), Chris Anagnostopoulos, Maria Anastassiadou, Anna Federica Castoldi, Adeline Cavelier, Tamara Coja, Federica Crivellente, Bruno Dujardin, Andy Hart, Wim Hooghe, Samira Jarrah, Kyriaki Machera, Elena Menegola, Francesca Metruccio, Christian Sieke, Luc Mohimont |
| المصدر: | EFSA Journal, Vol 20, Iss 10, Pp n/a-n/a (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Chemical technology |
| مصطلحات موضوعية: | cumulative assessment groups, cumulative risk assessment, pesticide residues, probabilistic modelling, craniofacial alterations, expert knowledge elicitation, Nutrition. Foods and food supply, TX341-641, Chemical technology, TP1-1185 |
| الوصف: | Abstract EFSA established cumulative assessment groups and conducted retrospective cumulative risk assessments for two types of craniofacial alterations (alterations due to abnormal skeletal development, head soft tissue alterations and brain neural tube defects) for 14 European populations of women in childbearing age. Cumulative acute exposure calculations were performed by probabilistic modelling using monitoring data collected by Member States in 2017, 2018 and 2019. A rigorous uncertainty analysis was performed using expert knowledge elicitation. Considering all sources of uncertainty, their dependencies and differences between populations, it was concluded with varying degrees of certainty that the MOET resulting from cumulative exposure is above 100 for the two types of craniofacial alterations. The threshold for regulatory consideration established by risk managers is therefore not exceeded. Considering the severity of the effects under consideration, it was also assessed whether the MOET is above 500. This was the case with varying levels of certainty for the head soft tissue alterations and brain neural tube defects. However, for the alterations due to abnormal skeletal development, it was found about as likely as not that the MOET is above 500 in most populations. For two populations, it was even found more likely that the MOET is below 500. These results were discussed in the light of the conservatism of the methodological approach. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1831-4732 |
| Relation: | https://doaj.org/toc/1831-4732 |
| DOI: | 10.2903/j.efsa.2022.7550 |
| URL الوصول: | https://doaj.org/article/499598268be341f4a2d87544cd85e417 |
| رقم الأكسشن: | edsdoj.499598268be341f4a2d87544cd85e417 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18314732 |
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| DOI: | 10.2903/j.efsa.2022.7550 |