دورية أكاديمية
أعرض في EDS

Usefulness of midregional proadrenomedullin to predict poor outcome in patients with community acquired pneumonia.

التفاصيل البيبلوغرافية
العنوان: Usefulness of midregional proadrenomedullin to predict poor outcome in patients with community acquired pneumonia.
المؤلفون: Susana Gordo-Remartínez, María Calderón-Moreno, Juan Fernández-Herranz, Ana Castuera-Gil, Mar Gallego-Alonso-Colmenares, Carolina Puertas-López, José A Nuevo-González, Domingo Sánchez-Sendín, Mercedes García-Gámiz, José A Sevillano-Fernández, Luis A Álvarez-Sala, Juan A Andueza-Lillo, José M de Miguel-Yanes
المصدر: PLoS ONE, Vol 10, Iss 6, p e0125212 (2015)
بيانات النشر: Public Library of Science (PLoS), 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: midregional proadrenomedullin (MR-proADM) is a prognostic biomarker in patients with community-acquired pneumonia (CAP). We sought to confirm whether MR-proADM added to Pneumonia Severity Index (PSI) improves the potential prognostic value of PSI alone, and tested to what extent this combination could be useful in predicting poor outcome of patients with CAP in an Emergency Department (ED).Consecutive patients diagnosed with CAP were enrolled in this prospective, single-centre, observational study. We analyzed the ability of MR-proADM added to PSI to predict poor outcome using receiver operating characteristic (ROC) curves, logistic regression and risk reclassification and comparing it with the ability of PSI alone. The primary outcome was "poor outcome", defined as the incidence of an adverse event (ICU admission, hospital readmission, or mortality at 30 days after CAP diagnosis).226 patients were included; 33 patients (14.6%) reached primary outcome. To predict primary outcome the highest area under curve (AUC) was found for PSI (0.74 [0.64-0.85]), which was not significantly higher than for MR-proADM (AUC 0.72 [0.63-0.81, p > 0.05]). The combination of PSI and MR-proADM failed to improve the predictive potential of PSI alone (AUC 0.75 [0.65-0.85, p=0.56]). Ten patients were appropriately reclassified when the combined PSI and MR-proADM model was used as compared with the model of PSI alone. Net reclassification improvement (NRI) index was statistically significant (7.69%, p = 0.03) with an improvement percentage of 3.03% (p = 0.32) for adverse event, and 4.66% (P = 0.02) for no adverse event.MR-proADM in combination with PSI may be helpful in individual risk stratification for short-term poor outcome of CAP patients, allowing a better reclassification of patients compared with PSI alone.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4452655?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0125212
URL الوصول: https://doaj.org/article/c49bfc014244419c91ca6ffbe4e5b069
رقم الأكسشن: edsdoj.49bfc014244419c91ca6ffbe4e5b069
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0125212