دورية أكاديمية
Crystal structure and conformational analysis of doxorubicin nitrate
| العنوان: | Crystal structure and conformational analysis of doxorubicin nitrate |
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| المؤلفون: | Logesh Mathivathanan, Guang Yang, Fenfei Leng, Raphael G. Raptis |
| المصدر: | Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 3, Pp 400-405 (2018) |
| بيانات النشر: | International Union of Crystallography, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Crystallography |
| مصطلحات موضوعية: | doxorubicin, anthracycline, conformation, intercalation, crystal structure, Crystallography, QD901-999 |
| الوصف: | Crystal structure determination of doxorubicin nitrate, (DoxH)NO3, systematic name (7S,9S)-7-{[(2R,4S,5S,6S)-4-azaniumyl-5-hydroxy-6-methyloxan-2-yl]oxy}-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracen-5,12-dione nitrate, shows two formula units present in the asymmetric unit. In the crystal lattice, hydrogen-bonded pairs of (DoxH+) cations and segregation of the aglycone and sugar moieties are observed. Inspection of molecular overlays reveals that the conformation of (DoxH)NO3 resembles that of DNA-intercalated, but not of protein-docked (DoxH)+. The structure was refined as a two-component twin. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2056-9890 20569890 |
| Relation: | http://scripts.iucr.org/cgi-bin/paper?S2056989018002955; https://doaj.org/toc/2056-9890 |
| DOI: | 10.1107/S2056989018002955 |
| URL الوصول: | https://doaj.org/article/49d20c18df7447b286b31c59c09563d9 |
| رقم الأكسشن: | edsdoj.49d20c18df7447b286b31c59c09563d9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20569890 |
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| DOI: | 10.1107/S2056989018002955 |