دورية أكاديمية
Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model
| العنوان: | Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model |
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| المؤلفون: | Li Huan, Yang Lixin, Zhao Xueying, Wang Jiucun, Qian Ji, Chen Hongyan, Fan Weiwei, Liu Hongcheng, Jin Li, Wang Weimin, Lu Daru |
| المصدر: | BMC Medical Genetics, Vol 13, Iss 1, p 118 (2012) |
| بيانات النشر: | BMC, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Internal medicine LCC:Genetics |
| مصطلحات موضوعية: | Chinese, Cumulative risk, Genetic risk score, Lung cancer, Risk assessment, Internal medicine, RC31-1245, Genetics, QH426-470 |
| الوصف: | Abstract Background Lung cancer is a complex polygenic disease. Although recent genome-wide association (GWA) studies have identified multiple susceptibility loci for lung cancer, most of these variants have not been validated in a Chinese population. In this study, we investigated whether a genetic risk score combining multiple. Methods Five single-nucleotide polymorphisms (SNPs) identified in previous GWA or large cohort studies were genotyped in 5068 Chinese case–control subjects. The genetic risk score (GRS) based on these SNPs was estimated by two approaches: a simple risk alleles count (cGRS) and a weighted (wGRS) method. The area under the receiver operating characteristic (ROC) curve (AUC) in combination with the bootstrap resampling method was used to assess the predictive performance of the genetic risk score for lung cancer. Results Four independent SNPs (rs2736100, rs402710, rs4488809 and rs4083914), were found to be associated with a risk of lung cancer. The wGRS based on these four SNPs was a better predictor than cGRS. Using a liability threshold model, we estimated that these four SNPs accounted for only 4.02% of genetic variance in lung cancer. Smoking history contributed significantly to lung cancer (P < 0.001) risk [AUC = 0.619 (0.603-0.634)], and incorporated with wGRS gave an AUC value of 0.639 (0.621-0.652) after adjustment for over-fitting. This model shows promise for assessing lung cancer risk in a Chinese population. Conclusion Our results indicate that although genetic variants related to lung cancer only added moderate discriminatory accuracy, it still improved the predictive ability of the assessment model in Chinese population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2350 |
| Relation: | http://www.biomedcentral.com/1471-2350/13/118; https://doaj.org/toc/1471-2350 |
| DOI: | 10.1186/1471-2350-13-118 |
| URL الوصول: | https://doaj.org/article/4a06596a17964bc48de3b34347386eb3 |
| رقم الأكسشن: | edsdoj.4a06596a17964bc48de3b34347386eb3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712350 |
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| DOI: | 10.1186/1471-2350-13-118 |