دورية أكاديمية
أعرض في EDS

Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

التفاصيل البيبلوغرافية
العنوان: Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms
المؤلفون: Zhipeng Qu, Hai Zhang, Moli Huang, Guangsen Shi, Zhiwei Liu, Pancheng Xie, Hui Li, Wei Wang, Guoqiang Xu, Yang Zhang, Ling Yang, Guocun Huang, Joseph S Takahashi, Weiping J Zhang, Ying Xu
المصدر: eLife, Vol 5 (2016)
بيانات النشر: eLife Sciences Publications Ltd, 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: circadian output gene, locomotor, ZBTB20, PROKR2, behavior rhythms, neurodegenerative disorders, Medicine, Science, Biology (General), QH301-705.5
الوصف: Many animals display morning and evening bimodal activities in the day/night cycle. However, little is known regarding the potential components involved in the regulation of bimodal behavioral rhythms in mammals. Here, we identified that the zinc finger protein gene Zbtb20 plays a crucial role in the regulation of bimodal activities in mice. Depletion of Zbtb20 in nerve system resulted in the loss of early evening activity, but the increase of morning activity. We found that Zbtb20-deficient mice exhibited a pronounced decrease in the expression of Prokr2 and resembled phenotypes of Prok2 and Prokr2-knockout mice. Injection of adeno-associated virus-double-floxed Prokr2 in suprachiasmatic nucleus could partly restore evening activity in Nestin-Cre; Zbtb20fl/fl (NS-ZB20KO) mice. Furthermore, loss of Zbtb20 in Foxg1 loci, but intact in the suprachiasmatic nucleus, was not responsible for the unimodal activity of NS-ZB20KO mice. Our study provides evidence that ZBTB20-mediated PROKR2 signaling is critical for the evening behavioral rhythms.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/17171; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.17171
URL الوصول: https://doaj.org/article/4a26c1f8a0f84f73a3aaca6c743daccd
رقم الأكسشن: edsdoj.4a26c1f8a0f84f73a3aaca6c743daccd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.17171