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Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation

التفاصيل البيبلوغرافية
العنوان: Asymmetric localization of the cell division machinery during Bacillus subtilis sporulation
المؤلفون: Kanika Khanna, Javier Lopez-Garrido, Joseph Sugie, Kit Pogliano, Elizabeth Villa
المصدر: eLife, Vol 10 (2021)
بيانات النشر: eLife Sciences Publications Ltd, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: cell division, FtsZ, FtsA, SpoIIE, peptidoglycan, cryo-electron tomography, Medicine, Science, Biology (General), QH301-705.5
الوصف: The Gram-positive bacterium Bacillus subtilis can divide via two modes. During vegetative growth, the division septum is formed at the midcell to produce two equal daughter cells. However, during sporulation, the division septum is formed closer to one pole to yield a smaller forespore and a larger mother cell. Using cryo-electron tomography, genetics and fluorescence microscopy, we found that the organization of the division machinery is different in the two septa. While FtsAZ filaments, the major orchestrators of bacterial cell division, are present uniformly around the leading edge of the invaginating vegetative septa, they are only present on the mother cell side of the invaginating sporulation septa. We provide evidence suggesting that the different distribution and number of FtsAZ filaments impact septal thickness, causing vegetative septa to be thicker than sporulation septa already during constriction. Finally, we show that a sporulation-specific protein, SpoIIE, regulates asymmetric divisome localization and septal thickness during sporulation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/62204; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.62204
URL الوصول: https://doaj.org/article/ad4a27e779a744568331f008f45cf027
رقم الأكسشن: edsdoj.4a27e779a744568331f008f45cf027
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.62204