دورية أكاديمية
The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses
العنوان: | The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses |
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المؤلفون: | Marinus Toman, John Joseph Wade, Alexei Verkhratsky, Mark Dallas, Angela Bithell, Bronac Flanagan, Jim Harkin, Liam McDaid |
المصدر: | Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023) |
بيانات النشر: | Nature Portfolio, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | Abstract Astrocytes display a highly complex, spongiform morphology, with their fine terminal processes (leaflets) exercising dynamic degrees of synaptic coverage, from touching and surrounding the synapse to being retracted from the synaptic region. In this paper, a computational model is used to reveal the effect of the astrocyte-synapse spatial relationship on ionic homeostasis. Specifically, our model predicts that varying degrees of astrocyte leaflet coverage influences concentrations of K+, Na+ and Ca2+, and results show that leaflet motility strongly influences Ca2+ uptake, as well as glutamate and K+ to a lesser extent. Furthermore, this paper highlights that an astrocytic leaflet that is in proximity to the synaptic cleft loses the ability to form a Ca2+ microdomain, whereas when the leaflet is remote from the synaptic cleft, a Ca2+ microdomain can form. This may have implications for Ca2+-dependent leaflet motility. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2045-2322 |
Relation: | https://doaj.org/toc/2045-2322 |
DOI: | 10.1038/s41598-023-30189-8 |
URL الوصول: | https://doaj.org/article/4a431c66bca744de805aebc154a16fe5 |
رقم الأكسشن: | edsdoj.4a431c66bca744de805aebc154a16fe5 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20452322 |
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DOI: | 10.1038/s41598-023-30189-8 |