Jeanne Martine Gunzinger, Nafsika Voulgari, Aleksandra Petrovic, Kattayoon Hashemi, Georgios KymionisLausanne University, Cornea and Refractive Surgery Department, Jules-Gonin Eye Hospital, Lausanne, SwitzerlandPurpose: To report the findings of anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) in two patients with peripheral hypertrophic subepithelial corneal degeneration (PHSD).Methods: Case series by retrospective chart review and imaging analysis of AS-OCT and IVCM.Results: Slit lamp examination of the two patients revealed a bilateral subepithelial-elevated fibrous tissue of the superior-nasal quadrant, as well as inferior-nasal in one of the patients. Best corrected visual acuity ranged from 20/25 to 20/15. AS-OCT showed continuous, homogenous, well-demarked hyperreflective subepithelial band associated with hyperreflectivity in the anterior stroma. IVCM demonstrated normal epithelial cell morphology and arrangement and a fibrous structure subepithelial and in the anterior stroma.Conclusion: AS-OCT and IVCM can facilitate the diagnosis of PHSD and differentiate it from other corneal entities that present peripheral opacifications.Keywords: peripheral hypertrophic subepithelial corneal degeneration, anterior segment optical coherence tomography, in vivo confocal microscopy, peripheral corneal opacification
PDF full text from Publisher 
Full Text Finder