دورية أكاديمية
أعرض في EDS

Eosinophils may serve as CEA-secreting cells for allergic bronchopulmonary aspergillosis (ABPA) patients

التفاصيل البيبلوغرافية
العنوان: Eosinophils may serve as CEA-secreting cells for allergic bronchopulmonary aspergillosis (ABPA) patients
المؤلفون: Yanfei Yang, qiqi Gao, Yangyi Jin, Mengdie Qi, Guohua Lu, HequanLi
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterized by an exaggerated response of the immune system to the fungus Aspergillus. This study aimed to assess the relationship between carcinoembryonic antigen (CEA) and eosinophils in ABPA patients. We describes a case of a 50-year-old patient who was diagnosed with ABPA presenting with high level of CEA and eosinophils. Besides,we used immunohistochemistry and immunofluorescence to identify eosinophils and CEA in sections which were obtained by Endobronchial ultrasound-guided transbronchial lung biopsy aspiration (EBUS-TBLB). The sections were then visualized using confocal microscopy. We also retrospectively analyzed a cohort of 37 ABPA patients between January 2013 and December 2019 in our hospital. We found the patient whose serum CEA levels were consistent with eosinophils during the follow-up (r = 0.929, P = 0.022). The positive expression of CEA and abnormal expression of eosinophils was higher in the ABPA tissue compared to the normal lung tissue. The co-localization was represented as pixels containing both red and green color in the image (with various shades of orange and yellow) which signified that eosinophils were immunohistochemically positive for CEA. Patients with higher levels of eosinophils had higher levels of CEA in the serum (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
39477886
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-021-83470-z
URL الوصول: https://doaj.org/article/4ac3947788684011b98afa8b6b14dd53
رقم الأكسشن: edsdoj.4ac3947788684011b98afa8b6b14dd53
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
39477886
DOI:10.1038/s41598-021-83470-z