Marine peptides are one of the important sources of biological peptides. Marine peptides have many types and are easy to be modified by metal ions. Marine peptides have natural advantages in the preparation of metal ion chelated peptides, and are expected to become a research hotspot of metal ion chelated peptides in the future. In this paper, the chelating mechanism of metal ion chelated peptides from ocean is reviewed. Single dentate chelating mode, double dentate chelating mode and α chelating mode, three chelating modes are described. At the same time, the effects of peptide size, amino acid type and position, some special residues on the chelation effect are summarized. The preparation and purification methods of metal chelate peptides from ocean are listed. The advantages and disadvantages of different methods are analyzed. In addition, the biological activities of metal ion chelated peptides such as promoting metal ion absorption, bacteriostatic and antioxidant are summarized. This paper can provide technical support for the preparation, functional activity analysis and chelating mechanism study of metal ion chelated peptides in the future.
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