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Effects of Venous Superdrainage and Arterial Supercharging on Dorsal Perforator Flap in a Rat Model.

التفاصيل البيبلوغرافية
العنوان: Effects of Venous Superdrainage and Arterial Supercharging on Dorsal Perforator Flap in a Rat Model.
المؤلفون: Jun Zheng, Shanshan Xi, Maochao Ding, Hong Li, Wei Xu, Maolin Tang, Shixin Chen
المصدر: PLoS ONE, Vol 11, Iss 8, p e0160942 (2016)
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: To comparatively assess the effects of venous superdrainage and arterial supercharging on dorsal perforator flap survival.Sixty male Sprague-Dawley rats (450-550g) were randomly divided into three groups (n = 20), including control group (Control) and experimental groups A (venous superdrainage, Exp. A) and B (arterial supercharging, Exp. B). At postoperative day 7, survival areas of the flaps were evaluated and all animals underwent angiography. Laser Doppler was used to evaluate flap perfusion from 0h to 7days after surgery. Histology with hematoxylin and eosin staining was used to count microvessels. Tissue of "Choke vessels"was excised for quantification of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) by western blot assay at 6h and 7days after surgery.In the Exp. A group, almost all flaps survived (98.2±1.6%); in the Exp. B and control group, survival areas accounted for 78.8±8.5% and 60.3±7.8%, respectively (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4981354?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0160942
URL الوصول: https://doaj.org/article/4b0fbd24dadb46db93063b5ebe7c99d6
رقم الأكسشن: edsdoj.4b0fbd24dadb46db93063b5ebe7c99d6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0160942