دورية أكاديمية
Pharmacological and computational evaluation of Sapodilla and its constituents for therapeutic potential in hyperactive gastrointestinal disorders
| العنوان: | Pharmacological and computational evaluation of Sapodilla and its constituents for therapeutic potential in hyperactive gastrointestinal disorders |
|---|---|
| المؤلفون: | Muhammad Bilal Riaz, Arif-ullah Khan, Neelam Gul Qazi |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 23, Iss 2, Pp 224-235 (2020) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | anti-diarrheal, anti-secretory, anti-spasmodic, anti-ulcer, manilkara zapota, molecular docking, Medicine |
| الوصف: | Objective(s): This study was designed to investigate various gastrointestinal effects of Manilkara zapota (Sapodilla), exploring its anti-diarrheal, anti-secretary, anti-spasmodic, anti-ulcer and anti-motility potential.Materials and Methods: Antidiarrheal and anti-secretary activities were investigated using castor oil induced diarrhea and castor oil induced fluid accumulation. Isolated rabbit jejunum tissues (antispasmodic) were employed for in vitro experiments. Antiulcer, antimotility and molecular docking were performed using ethanol-HCl induced ulcer assay, charcoal meal transit time and Auto Doc Vina.Results: Mz.Cr exhibited protection against castor oil-induced diarrhea (PConclusion: In present study, M. zapota is reported to exhibits anti-diarrheal, anti-secretory, anti-spasmodic, anti-motility, anti-ulcer effects and computational binding affinities against gastrointestinal targets. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | http://ijbms.mums.ac.ir/article_14287_dbc8a00e6a98d891a701bd8cb71e017c.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2019.35595.8488 |
| URL الوصول: | https://doaj.org/article/4b5b2465beb447e9b32f5b11f4e7e780 |
| رقم الأكسشن: | edsdoj.4b5b2465beb447e9b32f5b11f4e7e780 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
|---|---|
| DOI: | 10.22038/ijbms.2019.35595.8488 |