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أعرض في EDS

A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.

التفاصيل البيبلوغرافية
العنوان: A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis.
المؤلفون: Jonas Rosendahl, Anke Tönjes, Dorit Schleinitz, Peter Kovacs, Johannes Wiegand, Claudia Ruffert, Moritz Jesinghaus, Robert Schober, Max Herms, Robert Grützmann, Hans-Ulrich Schulz, Felix Stickel, Jens Werner, Peter Bugert, Matthias Blüher, Michael Stumvoll, Stephan Böhm, Thomas Berg, Henning Wittenburg, Joachim Mössner, Rene te Morsche, Monique Derikx, Volker Keim, Heiko Witt, Joost P H Drenth
المصدر: PLoS ONE, Vol 7, Iss 1, p e29433 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND: Chronic pancreatitis (CP) is an inflammatory disease that in some patients leads to exocrine and endocrine dysfunction. In industrialized countries the most common aetiology is chronic alcohol abuse. Descriptions of associated genetic alterations in alcoholic CP are rare. However, a common PNPLA3 variant (p.I148M) is associated with the development of alcoholic liver cirrhosis (ALC). Since, alcoholic CP and ALC share the same aetiology PNPLA3 variant (p.I148M) possibly influences the development of alcoholic CP. METHODS: Using melting curve analysis we genotyped the variant in 1510 patients with pancreatitis or liver disease (961 German and Dutch alcoholic CP patients, 414 German patients with idiopathic or hereditary CP, and 135 patients with ALC). In addition, we included in total 2781 healthy controls in the study. RESULTS: The previously published overrepresentation of GG-genotype was replicated in our cohort of ALC (p-value
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3262779?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0029433
URL الوصول: https://doaj.org/article/c4b840d3972f47b0b4dc6c4e0009e0a0
رقم الأكسشن: edsdoj.4b840d3972f47b0b4dc6c4e0009e0a0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0029433