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Natalizumab for the treatment of relapsing multiple sclerosis

التفاصيل البيبلوغرافية
العنوان: Natalizumab for the treatment of relapsing multiple sclerosis
المؤلفون: Richard A Rudick, Michael A Panzara
المصدر: Biologics: Targets & Therapy, Vol 2008, Iss Issue 2, Pp 189-199 (2008)
بيانات النشر: Dove Medical Press, 2008.
سنة النشر: 2008
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: Medicine (General), R5-920
الوصف: Richard A Rudick1, Michael A Panzara21Cleveland Clinic Foundation, Cleveland, OH, USA; 2Biogen Idec, Inc., Cambridge, MA, USAAbstract: Natalizumab is an α4-integrin antagonist approved as monotherapy for patients with relapsing multiple sclerosis (MS), based on demonstrated efficacy in the pivotal AFFIRM study (N = 942). Natalizumab monotherapy reduced risk of disability progression by 42%–54% and annualized relapse rate by 68% during a period of 2 years. Natalizumab was also associated with significant reductions in number of T2-hyperintense, gadolinium-enhancing, and T1-hypointense lesions and in volume of T2-hyperintense lesions (all p < 0.001) on magnetic resonance imaging. Furthermore, natalizumab-treated patients in AFFIRM experienced significant improvements from baseline in the physical and mental components of the Short Form-36 (p ≤ 0.01) and a 35% reduction in risk of clinically significant vision loss (p = 0.008 vs placebo). Natalizumab was well tolerated in phase 3 studies. Common adverse events were generally mild and included headache, fatigue, urinary tract infections, and arthralgia. Serious adverse events were similar between treatment groups. The incidence of serious hypersensitivity reactions associated with natalizumab was
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1177-5475
1177-5491
Relation: http://www.dovepress.com/natalizumab-for-the-treatment-of-relapsing-multiple-sclerosis-a1725; https://doaj.org/toc/1177-5475; https://doaj.org/toc/1177-5491
URL الوصول: https://doaj.org/article/4b8f45d87cdf40a88c04b2ca437e248d
رقم الأكسشن: edsdoj.4b8f45d87cdf40a88c04b2ca437e248d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11775475
11775491