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Using routine health data to evaluate the impact of indoor residual spraying on malaria transmission in Madagascar

التفاصيل البيبلوغرافية
العنوان: Using routine health data to evaluate the impact of indoor residual spraying on malaria transmission in Madagascar
المؤلفون: Sarah Burnett, Emily R Hilton, Saraha Rabeherisoa, Herizo Ramandimbiarijaona, Julie Rajaratnam, Allison Belemvire, Laurent Kapesa, Sarah Zohdy, Catherine Dentinger, Timothee Gandaho, Djenam Jacob, Celestin Razafinjato
المصدر: BMJ Global Health, Vol 8, Iss 7 (2023)
بيانات النشر: BMJ Publishing Group, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine (General)
LCC:Infectious and parasitic diseases
مصطلحات موضوعية: Medicine (General), R5-920, Infectious and parasitic diseases, RC109-216
الوصف: Introduction Indoor residual spraying (IRS) and insecticide-treated bed nets (ITNs) are cornerstone malaria prevention methods in Madagascar. This retrospective observational study uses routine data to evaluate the impacts of IRS overall, sustained IRS exposure over multiple years and level of spray coverage (structures sprayed/found) in nine districts where non-pyrethroid IRS was deployed to complement standard pyrethroid ITNs from 2017 to 2020.Methods Multilevel negative-binomial generalised linear models were fit to estimate the effects of IRS exposure overall, consecutive years of IRS exposure and spray coverage level on monthly all-ages population-adjusted malaria cases confirmed by rapid diagnostic test at the health facility level. The study period extended from July 2016 to June 2021. Facilities with missing data and non-geolocated communes were excluded. Facilities in IRS districts were matched with control facilities by propensity score analysis. Models were controlled for ITN survivorship, mass drug administration coverage, precipitation, enhanced vegetation index, seasonal effects and district. Predicted cases under a counterfactual no IRS scenario and number of cases averted by IRS were estimated using the fitted models.Results Exposure to IRS overall reduced case incidence by an estimated 30.3% from 165.8 cases per 1000 population (95% CI=139.7 to 196.7) under a counterfactual no IRS scenario, to 114.3 (95% CI=96.5 to 135.3) over 12 months post-IRS campaign in nine districts. A third year of IRS reduced malaria cases 30.9% more than a first year (incidence rate ratio (IRR)=0.578, 95% CI=0.578 to 0.825, p0.05). Coverage of 86%–90% was associated with a 19.7% reduction in incidence (IRR=0.803, 95% CI=0.690 to 0.934, p=0.005) compared with coverage ≤85%, although these results were not robust to sensitivity analysis.Conclusion This study demonstrates that non-pyrethroid IRS appears to substantially reduce malaria incidence in Madagascar and that sustained implementation of IRS over three years confers additional benefits.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2059-7908
Relation: https://gh.bmj.com/content/8/7/e010818.full; https://doaj.org/toc/2059-7908
DOI: 10.1136/bmjgh-2022-010818
URL الوصول: https://doaj.org/article/e4babbea999f400684a522e7d6a3cadd
رقم الأكسشن: edsdoj.4babbea999f400684a522e7d6a3cadd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20597908
DOI:10.1136/bmjgh-2022-010818