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CD72 gene expression in children suffering from primary immune thrombocytopenia and its correlation with the disease activity

التفاصيل البيبلوغرافية
العنوان: CD72 gene expression in children suffering from primary immune thrombocytopenia and its correlation with the disease activity
المؤلفون: Yasmen A. Mohamed, Dalia S. Morgan, Mostafa M. ELsaghier, Rehab M. Abd-Elkareem
المصدر: Beni-Suef University Journal of Basic and Applied Sciences, Vol 12, Iss 1, Pp 1-7 (2023)
بيانات النشر: SpringerOpen, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine (General)
LCC:Science
مصطلحات موضوعية: ITP, B lymphocytes, CD72, RT-PCR, Medicine (General), R5-920, Science
الوصف: Abstract Background Immune thrombocytopenia is a condition in which the immune system attacks platelets, leading to a low platelet count. CD72 is a co-receptor found on B cells during all developmental stages except those of plasma cells. Activation of CD72 promotes B cell growth and differentiation. We aimed to investigate the expression and role of CD72 in pediatric immune thrombocytopenia, as well as its correlation with disease pathogenesis and activity. The study involved 60 children diagnosed with ITP and 40 healthy controls, who were matched accordingly. All participants underwent a thorough medical history assessment and clinical examination. The RT-PCR method was utilized to determine the level of CD72 expression. Results CD72 expression level was considerably higher in cases than in controls (P-value
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2314-8543
Relation: https://doaj.org/toc/2314-8543
DOI: 10.1186/s43088-023-00447-9
URL الوصول: https://doaj.org/article/4bc635b0e01e4b558431322b768bcfbe
رقم الأكسشن: edsdoj.4bc635b0e01e4b558431322b768bcfbe
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23148543
DOI:10.1186/s43088-023-00447-9