دورية أكاديمية
Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing
| العنوان: | Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing |
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| المؤلفون: | Yannick Stahl, Iyad Kabar, Hauke Heinzow, Benjamin Maasoumy, Birgit Bremer, Heiner Wedemeyer, Hartmut H.-J. Schmidt, Thomas Pietschmann, Bernhard Schlevogt, Patrick Behrendt |
| المصدر: | Emerging Microbes and Infections, Vol 12, Iss 2 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| مصطلحات موضوعية: | Hepatitis E virus, dynamics, diagnostics, ELISA, antigen testing, antibodies, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| الوصف: | Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis. Numerous studies have investigated the dynamics of HEV infection markers, but the most suitable marker for diagnosing ongoing or recent HEV infection remains to be determined. Recent evidence suggests that serum antigen testing is superior to serum IgM and RNA quantification. Moreover, it has been found that infected individuals excrete HEV antigen in significant quantities through urine. To address this question, we conducted a longitudinal analysis involving 16 patients with acute or chronic HEV infection in an area where genotype 3 HEV is prevalent. Our findings indicate that the diagnostic and monitoring capabilities of antigen testing for HEV infection can be further enhanced by measuring it in urine. Additionally, we were able to demonstrate that this enhancement is likely due to the presence of HEV-reactive IgG in blood plasma, which hampers efficient detection of HEV antigen through sandwich ELISA. In conclusion, urine-based antigen testing appears to be superior to measuring anti-HEV antibodies or viral RNA for diagnosing suspected HEV infection and monitoring ongoing infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 22221751 2222-1751 |
| Relation: | https://doaj.org/toc/2222-1751 |
| DOI: | 10.1080/22221751.2023.2251598 |
| URL الوصول: | https://doaj.org/article/4bd99d018d8f4f499d2695a8b3e51829 |
| رقم الأكسشن: | edsdoj.4bd99d018d8f4f499d2695a8b3e51829 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 22221751 |
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| DOI: | 10.1080/22221751.2023.2251598 |