دورية أكاديمية
Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice
| العنوان: | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
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| المؤلفون: | Zahra Mazrooei, Hossein Tahmasebi Dehkordi, Maryam Hashemi Shahraki, Zahra Lorigooini, Elham Zarean, Hossein Amini-khoei |
| المصدر: | Heliyon, Vol 9, Iss 4, Pp e15550- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Ellagic acid, Social isolation stress, Neuroinflammation, Depression, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Recent studies have been demonstrated that neuroinflammation plays a crucial role in the pathophysiology of depression. Therefore, anti-inflammatory medications could be regarded as a potentially effective treatments for depression. Ellagic acid (EA) is a natural polyphenol with antioxidant and anti-inflammatory properties. This study aimed to evaluate the antidepressant-like effect of EA in a mouse model of social isolation stress (SIS), considering its potential anti-neuroinflammatory properties. In this study, 48 male mice were divided into six groups (n = 8), including saline-treated control (socially conditioned (SC)) group and SIS (isolation conditioned (IC)) groups treated with saline or EA at doses of 12.5, 25, 50, and 100 mg/kg, respectively. Saline and EA were administrated intraperitoneally for 14 constant days. Immobility time in the forced swimming test (FST) and grooming activity time in the splash test were measured. The gene expression of inflammatory cytokines relevant to neuroinflammation was assessed in the hippocampus by real-time PCR. Results showed that SIS significantly increased immobility time in the FST and reduced grooming activity time in the splash test. In addition, the expression of inflammatory genes, including TNF-α, IL-1β, and TLR4 increased in IC mice's hippocampi. Findings showed that EA decreased immobility time in the FST and increased grooming activity time in the splash test. Moreover, EA attenuated neuroimmune-response in the hippocampus. In conclusion, finding determined that EA, through attenuation of neuroinflammation in the hippocampus, partially at least, exerted an antidepressant-like effect in the mouse model of SIS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023027573; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e15550 |
| URL الوصول: | https://doaj.org/article/4beed831ded740ec8fad8b8dc5e4bec2 |
| رقم الأكسشن: | edsdoj.4beed831ded740ec8fad8b8dc5e4bec2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e15550 |