دورية أكاديمية
Worth a local treatment? – Analysis of modern radiotherapy concepts for oligometastatic prostate cancer
| العنوان: | Worth a local treatment? – Analysis of modern radiotherapy concepts for oligometastatic prostate cancer |
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| المؤلفون: | M. Oertel, S. Scobioala, K. Kroeger, A. Baehr, L. Stegger, U. Haverkamp, M. Schäfers, H.-T. Eich |
| المصدر: | Radiation Oncology, Vol 13, Iss 1, Pp 1-8 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Prostate cancer, Lymph-node recurrence, IMRT, Salvage therapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background Prostate cancer (PCA) is the most-prevalent non-skin cancer in men worldwide. Nevertheless, the treatment of oligometastatic, especially lymph-node (ln) recurrent, PCA remains elusive. The aim of our study was to provide insights in radiotherapy (RT)-treatment of recurrent PCA exhibiting ln- or osseous (oss)-oligometastases. Methods Between April 2012 and April 2017, 27 oligometastatic PCA patients (19 ln and 8 single oss) were treated with RT at our institution. Results The metastasis-free survival (MFS) was 24.8 m (22.0–36.0 m) and 25.4 m (23.9–28.1 m) for the ln- and oss-subgroup resulting in 1-year MFS of 75.4 and 100% and 2-year MFS of 58.7 and 83.3% for ln- and oss-metastatic patients, respectively. Of notice, none of the recurrences for ln-patients was in the RT-field, constituting a local control of 100%. Within the ln-group, pre-RT median-PSA was 2.6 ng/ml, median post-RT PSA was 0.3 ng/ml, which was significant (p = 0.003). Median biochemical-free survival (bfS) was 12.2 m. PCA that was initially confined to the prostate had a better bfS (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1748-717X |
| Relation: | http://link.springer.com/article/10.1186/s13014-018-1118-7; https://doaj.org/toc/1748-717X |
| DOI: | 10.1186/s13014-018-1118-7 |
| URL الوصول: | https://doaj.org/article/4c30491211e342b583b0a00eb147b17e |
| رقم الأكسشن: | edsdoj.4c30491211e342b583b0a00eb147b17e |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1748717X |
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| DOI: | 10.1186/s13014-018-1118-7 |