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Downregulation Of Extracellular Matrix And Cell Adhesion Molecules In Cumulus Cells Of Infertile Polycystic Ovary Syndrome Women With And Without Insulin Resistance

التفاصيل البيبلوغرافية
العنوان: Downregulation Of Extracellular Matrix And Cell Adhesion Molecules In Cumulus Cells Of Infertile Polycystic Ovary Syndrome Women With And Without Insulin Resistance
المؤلفون: Fatemeh Hassani, Shahrbanoo Oryan, Poopak Eftekhari-Yazdi, Masood Bazrgar, Ashraf Moini, Nahid Nasiri, Ali Sharifi-Zarchi
المصدر: Cell Journal, Vol 21, Iss 1, Pp 35-42 (2018)
بيانات النشر: Royan Institute (ACECR), Tehran, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Cumulus Cells, Extracellular Matrix, Gene Expression, Insulin Resistance, Polycystic Ovary Syndrome, Medicine, Science
الوصف: Objective The extracellular matrix (ECM) of the cumulus oocyte complex (COC) is composed of several molecules that have different roles during follicle development. This study aims to explore gene expression profiles for ECM and cell adhesion molecules in the cumulus cells of polycystic ovary syndrome (PCOS) patients based on their insulin sensitivity following controlled ovarian stimulation (COS). Materials And Methods In this prospective case-control study enrolled 23 women less than 36 years of age who participated in an intracytoplasmic sperm injection (ICSI) program. Patients were subdivided into 3 groups: control (n=8, fertile women with male infertility history), insulin resistant (IR) PCOS (n=7), and insulin sensitive (IS) PCOS (n=8). We compared 84 ECM component and adhesion molecule gene expressions by quantitative real-time polymerase chain reaction array (qPCR-array) among the groups. Results We noted that 21 of the 84 studied genes differentially expressed among the groups, from which 18 of these genes downregulated. Overall, comparison of PCOS cases with controls showed downregulation of extracellular matrix protein 1 (ECM1); catenin (cadherin-associated protein), alpha 1 (CTNNA1); integrin, alpha 5 (ITGA5); laminin, alpha 3 (LAMA3); laminin, beta 1 (LAMB1); fibronectin 1 (FN1); and integrin, alpha 7 (ITGA7). In the IS group, there was upregulation of ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ADAMTS8) and neural cell adhesion molecule 1 (NCAM1) compared with the controls (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2228-5806
2228-5814
Relation: https://celljournal.org/journal/article/abstract/5576; https://doaj.org/toc/2228-5806; https://doaj.org/toc/2228-5814
DOI: 10.22074/cellj.2019.5576
URL الوصول: https://doaj.org/article/4c54936c7ba942eb8d8f589285b18a27
رقم الأكسشن: edsdoj.4c54936c7ba942eb8d8f589285b18a27
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22285806
22285814
DOI:10.22074/cellj.2019.5576