التفاصيل البيبلوغرافية
العنوان:
Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy
المؤلفون:
Marie-Eve Wedge , Victoria A. Jennings , Mathieu J. F. Crupi , Joanna Poutou , Taylor Jamieson , Adrian Pelin , Giuseppe Pugliese , Christiano Tanese de Souza , Julia Petryk , Brian J. Laight , Meaghan Boileau , Zaid Taha , Nouf Alluqmani , Hayley E. McKay , Larissa Pikor , Sarwat Tahsin Khan , Taha Azad , Reza Rezaei , Bradley Austin , Xiaohong He , David Mansfield , Elaine Rose , Emily E. F. Brown , Natalie Crawford , Almohanad Alkayyal , Abera Surendran , Ragunath Singaravelu , Dominic G. Roy , Gemma Migneco , Benjamin McSweeney , Mary Lynn Cottee , Egon J. Jacobus , Brian A. Keller , Takafumi N. Yamaguchi , Paul C. Boutros , Michele Geoffrion , Katey J. Rayner , Avijit Chatterjee , Rebecca C. Auer , Jean-Simon Diallo , Derrick Gibbings , Benjamin R. tenOever , Alan Melcher , John C. Bell , Carolina S. Ilkow
المصدر:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
بيانات النشر:
Nature Portfolio, 2022.
سنة النشر:
2022
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
RNA-based viruses can be engineered to express artificial microRNAs (amiRNAs). Here, the authors identify a candidate amiRNA that confers a replicative advantage to oncolytic viruses, enhancing their anticancer potency, and show that intercellular transfer of extracellular vesicles carrying the amiRNA promotes bystander killing of uninfected cancer cells.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-022-29526-8
URL الوصول:
https://doaj.org/article/4c63ee51ae0d403a99532dab542cb349
رقم الأكسشن:
edsdoj.4c63ee51ae0d403a99532dab542cb349
قاعدة البيانات:
Directory of Open Access Journals
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