دورية أكاديمية
Cardiac allograft vasculopathy outcomes among donation after circulatory death heart transplant recipients
| العنوان: | Cardiac allograft vasculopathy outcomes among donation after circulatory death heart transplant recipients |
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| المؤلفون: | Antoinette S. Birs, MD, Quan M. Bui, MD, Yan Gernhofer, Antonio Duran, MD, Lucas Keyt, MD, Kevin Paternostro, MD, Jeffrey Ding, Eric Adler, MD, Lawrence Ang, MD, Marcus A. Urey, MD, Mark J. Kearns, MD, Nicholas Wettersten, MD, Victor Pretorius, MBchB |
| المصدر: | JHLT Open, Vol 4, Iss , Pp 100065- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Surgery LCC:Specialties of internal medicine |
| مصطلحات موضوعية: | cardiac allograft vasculopathy, donation after circulatory death, intravascular ultrasound, heart transplantation, heart transplant outcomes, Surgery, RD1-811, Specialties of internal medicine, RC581-951 |
| الوصف: | Background: Cardiac allograft vasculopathy (CAV) accounts for significant long-term morbidity and mortality in heart transplant recipients; limited data exist for donation after circulatory death (DCD). Intravascular ultrasound (IVUS) assessment is a gold standard for early diagnosis of CAV and has strong prognostic power. Methods: We evaluated all consecutive circulatory and brain death heart transplant recipients from January 2020 to March 2022. Patients were followed for need for percutaneous coronary intervention (PCI), development of severe allograft vasculopathy, or death. Among 143 heart transplant recipients, 39 received circulatory death and 104 received brain death hearts. Results: Baseline characteristics were similar between groups: median age (56.3 vs 53.7 years, p = 0.290), female sex (15% vs 26%, p = 0.265), and sirolimus use (69% vs 53%, p = 0.116). At 1 year, there were no significant differences in maximal intimal thickness (0.49 vs 0.46 mm, p = 0.861) or Stanford classification. During a median follow-up of 793 days [interquartile ranges 618, 1003], there was no difference in the unadjusted or adjusted primary composite outcome of death, PCI, or International Society of Heart and Lung Transplantation cardiac allograft vasculopathy maximal intimal thickness ≥0.6 mm (unadjusted hazard ratio (HR) 0.42, 95% confidence interval (CI): 0.05, 3.48, p = 0.42), event rate 9.6% vs 2.6%, p = 0.29, nor was there a difference in death, PCI or severe IVUS disease (HR 1.44, 95% CI 0.81, 2.56, p = 0.21). Conclusion: In DCD heart transplant recipients, circulatory death donors did not have a significantly higher risk for coronary allograft vasculopathy by IVUS or related complications at 1 year following transplantation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2950-1334 89604202 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2950133424000144; https://doaj.org/toc/2950-1334 |
| DOI: | 10.1016/j.jhlto.2024.100065 |
| URL الوصول: | https://doaj.org/article/dc4cb94a2b7e42e89604202006f5913b |
| رقم الأكسشن: | edsdoj.4cb94a2b7e42e89604202006f5913b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 29501334 89604202 |
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| DOI: | 10.1016/j.jhlto.2024.100065 |