دورية أكاديمية
miR-1 inhibits migration of gastric cancer cells
| العنوان: | miR-1 inhibits migration of gastric cancer cells |
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| المؤلفون: | Xiu-qing Lin, Wei Wu, Xin Chen, Ren-pin Chen, Fang Wu, Zhou-feng Chen, Er-jiong Huang, Chao Chen |
| المصدر: | Frontiers in Bioscience-Landmark, Vol 25, Iss 3, Pp 452-462 (2020) |
| بيانات النشر: | IMR Press, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biochemistry LCC:Biology (General) |
| مصطلحات موضوعية: | mir-1, epithelial-mesenchymal transition, gastric cancer, sorcin, Biochemistry, QD415-436, Biology (General), QH301-705.5 |
| الوصف: | Gastric cancer is the fourth most common malignancy world-wide that bears a high mortality by invasiveness and metastases. To this end, we examined the role of miR-1 in mobility and migration of gastric cancer cells. miR-1 was down-regulated and Sorcin, which supports invasion, was highly expressed in gastric cancer cell lines as compared to the control. The overexpression of miR-1 significantly inhibited the mobility and migration of gastric cancer cells, while, its knockdown exerted an oppoiste effect. In addition, while overexpression of miR-1 suppressed the expression of Sorcin, the siRNA knockdown of Sorcin significantly counteracted the effect of miR-1 inhibitor on cell invasion and migration of gastric cancer cells. A miR-1 mimic decreased while its inhibitor increased the MMP-7 and VEGF required for invasion. Taken together, the findings support the view that miR-1 controls the mobility and migration of gastric cancer cells and might be a therapeutic target for blocking gastric cancer invasion. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2768-6701 |
| Relation: | https://www.imrpress.com/journal/FBL/25/3/10.2741/4813; https://doaj.org/toc/2768-6701 |
| DOI: | 10.2741/4813 |
| URL الوصول: | https://doaj.org/article/4cdd9005b8814ddbb276112eeb8e0e27 |
| رقم الأكسشن: | edsdoj.4cdd9005b8814ddbb276112eeb8e0e27 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 27686701 |
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| DOI: | 10.2741/4813 |