دورية أكاديمية
أعرض في EDS

A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma.

التفاصيل البيبلوغرافية
العنوان: A retrospective review of the prognostic value of ALDH-1, Bmi-1 and Nanog stem cell markers in esophageal squamous cell carcinoma.
المؤلفون: Cheng-Cheng Hwang, Shin Nieh, Chien-Hong Lai, Chien-Sheng Tsai, Liang-Che Chang, Chung-Ching Hua, Wen-Ying Chi, Hui-Ping Chien, Chih-Wei Wang, Siu-Cheung Chan, Tsan-Yu Hsieh, Jim-Ray Chen
المصدر: PLoS ONE, Vol 9, Iss 8, p e105676 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Stem cell markers are upregulated in various cancers and have potential as prognostic indicators. The objective of this study was to determine the expression of three stem cell markers, aldehyde dehydrogenase 1 (ALDH-1), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1), and Nanog, in esophageal squamous cell carcinoma (ESCC) tissues. Immunohistochemistry was used to measure the expression of ALDH-1, Bmi-1, and Nanog in ESCC tissues from 41 patients who received pre-operative chemoradiation. We evaluated the relationship between expression of these markers, and clinicopathological features, tumor regression grade (TRG), and 5-year overall survival (OS). There were no significant associations of ALDH-1 or Bmi-1 expression with age, gender, clinical stage, and treatments (p>0.05). However, patients with Nanog-positive tumors were significantly older than those whose tumors were Nanog-negative (p = 0.033). TRG after treatment was significantly associated with expression of ALDH-1 (p = 0.001), Bmi-1 (p = 0.004), and Nanog (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4141830?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0105676
URL الوصول: https://doaj.org/article/4d1ea6c9af894ab389b02349432abf2b
رقم الأكسشن: edsdoj.4d1ea6c9af894ab389b02349432abf2b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0105676