دورية أكاديمية
Breast cancer organoids and their applications for precision cancer immunotherapy
العنوان: | Breast cancer organoids and their applications for precision cancer immunotherapy |
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المؤلفون: | Dandan Guan, Xiaozhen Liu, Qingyang Shi, Bangjie He, Chaopeng Zheng, Xuli Meng |
المصدر: | World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-11 (2023) |
بيانات النشر: | BMC, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Surgery LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | Breast cancer, Immunotherapy, Organoid, Tumor microenvironment, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | Abstract Immunotherapy is garnering increasing attention as a therapeutic strategy for breast cancer (BC); however, the application of precise immunotherapy in BC has not been fully studied. Further studies on BC immunotherapy have a growing demand for preclinical models that reliably recapitulate the composition and function of the tumor microenvironment (TME) of BC. However, the classic two-dimensional in vitro and animal in vivo models inadequately recapitulate the intricate TME of the original tumor. Organoid models which allow the regular culture of primitive human tumor tissue are increasingly reported that they can incorporate immune components. Therefore, organoid platforms can be used to replicate the BC–TME to achieve the immunotherapeutic reaction modeling and facilitate relevant preclinical trial. In this study, we have investigated different organoid culture methods for BC–TME modeling and their applications for precision immunotherapy in BC. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1477-7819 |
Relation: | https://doaj.org/toc/1477-7819 |
DOI: | 10.1186/s12957-023-03231-2 |
URL الوصول: | https://doaj.org/article/4d42eab0859f480696bd9a8ed8112edb |
رقم الأكسشن: | edsdoj.4d42eab0859f480696bd9a8ed8112edb |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14777819 |
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DOI: | 10.1186/s12957-023-03231-2 |