دورية أكاديمية
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Breast cancer organoids and their applications for precision cancer immunotherapy

التفاصيل البيبلوغرافية
العنوان: Breast cancer organoids and their applications for precision cancer immunotherapy
المؤلفون: Dandan Guan, Xiaozhen Liu, Qingyang Shi, Bangjie He, Chaopeng Zheng, Xuli Meng
المصدر: World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-11 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Surgery
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Breast cancer, Immunotherapy, Organoid, Tumor microenvironment, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Immunotherapy is garnering increasing attention as a therapeutic strategy for breast cancer (BC); however, the application of precise immunotherapy in BC has not been fully studied. Further studies on BC immunotherapy have a growing demand for preclinical models that reliably recapitulate the composition and function of the tumor microenvironment (TME) of BC. However, the classic two-dimensional in vitro and animal in vivo models inadequately recapitulate the intricate TME of the original tumor. Organoid models which allow the regular culture of primitive human tumor tissue are increasingly reported that they can incorporate immune components. Therefore, organoid platforms can be used to replicate the BC–TME to achieve the immunotherapeutic reaction modeling and facilitate relevant preclinical trial. In this study, we have investigated different organoid culture methods for BC–TME modeling and their applications for precision immunotherapy in BC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1477-7819
Relation: https://doaj.org/toc/1477-7819
DOI: 10.1186/s12957-023-03231-2
URL الوصول: https://doaj.org/article/4d42eab0859f480696bd9a8ed8112edb
رقم الأكسشن: edsdoj.4d42eab0859f480696bd9a8ed8112edb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14777819
DOI:10.1186/s12957-023-03231-2