دورية أكاديمية
Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis
| العنوان: | Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis |
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| المؤلفون: | Jingsi Zhang, Xiaoyan Li, Zhuoran Zhang, Jintao Zhang, Limin Ma, Shanshan Wang, Xin Guo, Huan Li, Baolong Pan, Qiao Niu |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 270, Iss , Pp 115860- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | Aluminum, Drp1, Mitochondrion, Necroptosis, PGAM5, RIP3, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Epidemiological studies from diverse global regions suggest a correlation between the accumulation of aluminum in the brain and the onset of various neurodegenerative diseases, including Alzheimer's disease, of which, neuronal cells death happen. Our previous research has found the potential of aluminum to induce neuronal cell death. A comprehensive exploration of the regulatory pathways influenced by aluminum in neuronal cell death could contribute to the development of strategies aimed at preventing the detrimental impact of aluminum on neuronal cells. This study is dedicated to exploring the impact of aluminum on mitochondrial homeostasis through the RIP3-PGAM5-Drp1 pathway, with a specific focus on its potential role in necroptosis. We observed that the inhibition of RIP3 function and the reduction in PGAM5 protein expression both mitigate aluminum-induced necroptosis in PC12 cells and enhance mitochondrial function. However, the inhibition of PGAM5 protein expression does not exert an impact on the expression of RIP3 and MLKL proteins. In summary, our study posits that aluminum can induce necroptosis in PC12 cells through the RIP3-PGAM5-Drp1 pathway. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651323013647; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2023.115860 |
| URL الوصول: | https://doaj.org/article/4d5e08e315fd468eab3f732939bcc335 |
| رقم الأكسشن: | edsdoj.4d5e08e315fd468eab3f732939bcc335 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2023.115860 |