دورية أكاديمية
The Emerging Importance of Cirsimaritin in Type 2 Diabetes Treatment
| العنوان: | The Emerging Importance of Cirsimaritin in Type 2 Diabetes Treatment |
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| المؤلفون: | Abdelrahim Alqudah, Rabaa Y. Athamneh, Esam Qnais, Omar Gammoh, Muna Oqal, Rawan AbuDalo, Hanan Abu Alshaikh, Nabil AL-Hashimi, Mohammad Alqudah |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 6, p 5749 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | cirsimaritin, insulin resistance, type 2 diabetes, oxidative stress, inflammation, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Cirsimaritin is a dimethoxy flavon that has different biological activities such as antiproliferative, antimicrobial, and antioxidant activities. This study aims to investigate the anti-diabetic effects of cirsimaritin in a high-fat diet and streptozotocin-(HFD/STZ)-induced rat model of type 2 diabetes mellitus (T2D). Rats were fed HFD, followed by a single low dose of STZ (40 mg/kg). HFD/STZ diabetic rats were treated orally with cirsimaritin (50 mg/kg) or metformin (200 mg/kg) for 10 days before terminating the experiment and collecting plasma, soleus muscle, adipose tissue, and liver for further downstream analysis. Cirsimaritin reduced the elevated levels of serum glucose in diabetic rats compared to the vehicle control group (p < 0.001). Cirsimaritin abrogated the increase in serum insulin in the treated diabetic group compared to the vehicle control rats (p < 0.01). The homeostasis model assessment of insulin resistance (HOMA-IR) was decreased in the diabetic rats treated with cirsimaritin compared to the vehicle controls. The skeletal muscle and adipose tissue protein contents of GLUT4 (p < 0.01 and p < 0.05, respectively) and pAMPK-α1 (p < 0.05) were upregulated following treatment with cirsimaritin. Cirsimaritin was able to upregulate GLUT2 and AMPK protein expression in the liver (p < 0.01, p < 0.001). Cirsimaritin reduced MDA, and IL-6 levels (p < 0.001), increased GSH levels (p < 0.001), and reduced GSSG levels (p < 0.001) in diabetic rats compared to the vehicle control. Cirsimaritin could represent a promising therapeutic agent to treat T2D. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 24065749 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/6/5749; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24065749 |
| URL الوصول: | https://doaj.org/article/4d921d423196478bacf2d93073275f9a |
| رقم الأكسشن: | edsdoj.4d921d423196478bacf2d93073275f9a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24065749 14220067 16616596 |
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| DOI: | 10.3390/ijms24065749 |