PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1

التفاصيل البيبلوغرافية
العنوان:	PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1
المؤلفون:	Alessandro Poli, Fabrizio A. Pennacchio, Andrea Ghisleni, Mariagrazia di Gennaro, Margaux Lecacheur, Paulina Nastały, Michele Crestani, Francesca M. Pramotton, Fabio Iannelli, Galina Beznusenko, Alexander A. Mironov, Valeria Panzetta, Sabato Fusco, Bhavwanti Sheth, Dimos Poulikakos, Aldo Ferrari, Nils Gauthier, Paolo A. Netti, Nullin Divecha, Paolo Maiuri
المصدر:	Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
بيانات النشر:	Nature Portfolio, 2023.
سنة النشر:	2023
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	PIP4Ks are phosphoinositide kinases often dysregulated in cancer. Here Poli and colleagues find that PIP4K2B is downregulated on soft substrates, and its depletion leads to altered nuclear mechanical properties and defects in cell spreading and motility.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-023-37064-0
URL الوصول:	https://doaj.org/article/4d9e3d61d6c2464f8d96e71e834db4ef
رقم الأكسشن:	edsdoj.4d9e3d61d6c2464f8d96e71e834db4ef
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-023-37064-0