دورية أكاديمية
أعرض في EDS

Quality of initial anticoagulant treatment and risk of CTEPH after acute pulmonary embolism.

التفاصيل البيبلوغرافية
العنوان: Quality of initial anticoagulant treatment and risk of CTEPH after acute pulmonary embolism.
المؤلفون: Gudula J A M Boon, Nienke van Rein, Harm Jan Bogaard, Yvonne M Ende-Verhaar, Menno V Huisman, Lucia J M Kroft, Felix J M van der Meer, Lilian J Meijboom, Petr Symersky, Anton Vonk Noordegraaf, Frederikus A Klok
المصدر: PLoS ONE, Vol 15, Iss 4, p e0232354 (2020)
بيانات النشر: Public Library of Science (PLoS), 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:The pathophysiology of chronic thromboembolic pulmonary hypertension (CTEPH) is not fully understood. Poor-quality anticoagulation may contribute to a higher risk of CTEPH after acute pulmonary embolism (PE), partly explaining the transition from acute PE to CTEPH. We assessed the association between the time in therapeutic range (TTR) of vitamin-K antagonist (VKA) treatment and incidence of CTEPH after a PE diagnosis. METHODS:Case-control study in which the time spent in, under and above therapeutic range was calculated in 44 PE patients who were subsequently diagnosed with CTEPH (cases). Controls comprised 150 consecutive PE patients in whom echocardiograms two years later did not show pulmonary hypertension. All patients were treated with VKA for at least 6 months after the PE diagnosis. Time in (TTR), under and above range were calculated. Mean differences between cases and controls were estimated by linear regression. RESULTS:Mean TTR during the initial 6-month treatment period was 72% in cases versus 78% in controls (mean difference -6%, 95%CI -12 to -0.1), mainly explained by more time above the therapeutic range in the cases. Mean difference of time under range was 0% (95%CI -6 to 7) and 2% (95CI% -3 to 7) during the first 3 and 6 months, respectively. In a multivariable model, adjusted odds ratios (ORs) for CTEPH were around unity considering different thresholds for 'poor anticoagulation', i.e. TTR
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0232354
URL الوصول: https://doaj.org/article/da4df8c485b54ad8a92d586bb3bedf18
رقم الأكسشن: edsdoj.4df8c485b54ad8a92d586bb3bedf18
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0232354