دورية أكاديمية
Targeting Mitochondria with ClpP Agonists as a Novel Therapeutic Opportunity in Breast Cancer
| العنوان: | Targeting Mitochondria with ClpP Agonists as a Novel Therapeutic Opportunity in Breast Cancer |
|---|---|
| المؤلفون: | Rohan Wedam, Yoshimi Endo Greer, David J. Wisniewski, Sarah Weltz, Manjari Kundu, Donna Voeller, Stanley Lipkowitz |
| المصدر: | Cancers, Vol 15, Iss 7, p 1936 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | breast cancer, mitochondria, cancer metabolism, ClpP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Breast cancer is the most frequently diagnosed malignancy worldwide and the leading cause of cancer mortality in women. Despite the recent development of new therapeutics including targeted therapies and immunotherapy, triple-negative breast cancer remains an aggressive form of breast cancer, and thus improved treatments are needed. In recent decades, it has become increasingly clear that breast cancers harbor metabolic plasticity that is controlled by mitochondria. A myriad of studies provide evidence that mitochondria are essential to breast cancer progression. Mitochondria in breast cancers are widely reprogrammed to enhance energy production and biosynthesis of macromolecules required for tumor growth. In this review, we will discuss the current understanding of mitochondrial roles in breast cancers and elucidate why mitochondria are a rational therapeutic target. We will then outline the status of the use of mitochondria-targeting drugs in breast cancers, and highlight ClpP agonists as emerging mitochondria-targeting drugs with a unique mechanism of action. We also illustrate possible drug combination strategies and challenges in the future breast cancer clinic. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15071936 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/15/7/1936; https://doaj.org/toc/2072-6694 |
| DOI: | 10.3390/cancers15071936 |
| URL الوصول: | https://doaj.org/article/e4e640a7a88a40a9922d66d403b1fccd |
| رقم الأكسشن: | edsdoj.4e640a7a88a40a9922d66d403b1fccd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15071936 20726694 |
|---|---|
| DOI: | 10.3390/cancers15071936 |