دورية أكاديمية

Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial

التفاصيل البيبلوغرافية
العنوان: Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial
المؤلفون: Annemarie B. Villadsen, Julie N. Holm-Jacobsen, Bala K. Prabhala, Caspar Bundgaard-Nielsen, Pam Huntjens, Jette B. Kornum, Karin Glavind, Peter D. C. Leutscher, Lars P. Christensen, Per B. Jeppesen, Suzette Sørensen, Louise T. S. Arenholt
المصدر: Nutrients, Vol 15, Iss 19, p 4165 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Nutrition. Foods and food supply
مصطلحات موضوعية: overactive bladder, isoflavones, red clover, urinary incontinence, postmenopause, Nutrition. Foods and food supply, TX341-641
الوصف: Postmenopausal women are at risk of developing an overactive bladder (OAB). Conventional vaginal estrogen has shown promise for symptom relief. Isoflavones have proven effective as an alternative to estrogen treatment against menopause-related symptoms. However, its effect on OAB symptoms has not been studied. This study investigates if fermented red clover isoflavones reduce OAB symptoms in postmenopausal women. In this randomized, double-blinded, placebo-controlled trial, women were administered red clover extract (RCE) or a placebo twice daily for three months. Women filled out the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and Urinary Incontinence Short Form (ICIQ-UI-SF), together with a fluid intake and voiding diary. A total of 33 women (16 in the RCE group and 17 in the placebo group) were included in the analysis. Baseline demographics and OAB characteristics were comparable across groups. Intake of RCE did not lead to significant relief in most urinary bladder symptom measures, although a significant reduction in the bother of urinary urgency (p = 0.033) and a tendency towards a decreased ICIQ-OAB score were observed (p = 0.056). In contrast, the placebo exhibited a significant decrease in the ICIQ-OAB score (p = 0.021) and in some diary outcomes. We found that an intake of isoflavones did not relieve OAB symptoms in postmenopausal women.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2072-6643
Relation: https://www.mdpi.com/2072-6643/15/19/4165; https://doaj.org/toc/2072-6643
DOI: 10.3390/nu15194165
URL الوصول: https://doaj.org/article/4e67d734f3e34554bd6b0d47796035e2
رقم الأكسشن: edsdoj.4e67d734f3e34554bd6b0d47796035e2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20726643
DOI:10.3390/nu15194165