دورية أكاديمية

Elevated Serum Melatonin under Constant Darkness Enhances Neural Repair in Spinal Cord Injury through Regulation of Circadian Clock Proteins Expression

التفاصيل البيبلوغرافية
العنوان: Elevated Serum Melatonin under Constant Darkness Enhances Neural Repair in Spinal Cord Injury through Regulation of Circadian Clock Proteins Expression
المؤلفون: Yunkyung Hong, Yunho Jin, Kanghui Park, Jeonghyun Choi, Hyunbon Kang, Sang-Rae Lee, Yonggeun Hong
المصدر: Journal of Clinical Medicine, Vol 8, Iss 2, p 135 (2019)
بيانات النشر: MDPI AG, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
مصطلحات موضوعية: environmental lighting condition, endogenous melatonin, spinal cord injury, circadian clock, neural remodeling, Medicine
الوصف: We investigated the effects of environmental lighting conditions regulating endogenous melatonin production on neural repair, following experimental spinal cord injury (SCI). Rats were divided into three groups randomly: the SCI + L/D (12/12-h light/dark), SCI + LL (24-h constant light), and SCI + DD (24-h constant dark) groups. Controlled light/dark cycle was pre-applied 2 weeks before induction of spinal cord injury. There was a significant increase in motor recovery as well as body weight from postoperative day (POD) 7 under constant darkness. However, spontaneous elevation of endogenous melatonin in cerebrospinal fluid was seen at POD 3 in all of the SCI rats, which was enhanced in SCI + DD group. Augmented melatonin concentration under constant dark condition resulted in facilitation of neuronal differentiation as well as inhibition of primary cell death. In the rostrocaudal region, elevated endogenous melatonin concentration promoted neural remodeling in acute phase including oligodendrogenesis, excitatory synaptic formation, and axonal outgrowth. The changes were mediated via NAS-TrkB-AKT/ERK signal transduction co-regulated by the circadian clock mechanism, leading to rapid motor recovery. In contrast, exposure to constant light exacerbated the inflammatory responses and neuroglial loss. These results suggest that light/dark control in the acute phase might be a considerable environmental factor for a favorable prognosis after SCI.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2077-0383
Relation: https://www.mdpi.com/2077-0383/8/2/135; https://doaj.org/toc/2077-0383
DOI: 10.3390/jcm8020135
URL الوصول: https://doaj.org/article/a4ebb3987b974468892a6059f1e18974
رقم الأكسشن: edsdoj.4ebb3987b974468892a6059f1e18974
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20770383
DOI:10.3390/jcm8020135