دورية أكاديمية
أعرض في EDS

Ongoing liver inflammation in patients with chronic hepatitis C and sustained virological response.

التفاصيل البيبلوغرافية
العنوان: Ongoing liver inflammation in patients with chronic hepatitis C and sustained virological response.
المؤلفون: Christoph Welsch, Mira Efinger, Michael von Wagner, Eva Herrmann, Stefan Zeuzem, Tania M Welzel, Christian M Lange
المصدر: PLoS ONE, Vol 12, Iss 2, p e0171755 (2017)
بيانات النشر: Public Library of Science (PLoS), 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:Novel direct-acting antiviral DAA combination therapies tremendously improved sustained virologic response (SVR) rates in patients with chronic HCV infection. SVR is typically accompanied by normalization of liver enzymes, however, hepatic inflammation, i.e. persistently elevated aminotransferase levels may persist despite HCV eradication. Aim: To investigate prevalence and risk factors for ongoing hepatic inflammation after SVR in two large patient cohorts. METHODS:This post-hoc analysis was based on prospectively collected demographic and clinical data from 834 patients with SVR after HCV treatment with either PegIFN- or DAA-based treatment regimens from the PRAMA trial (n = 341) or patients treated at our outpatient clinic (n = 493). RESULTS:We observed an unexpected high prevalence of post-SVR inflammation, including patients who received novel IFN-free DAA-based therapies. Up to 10% of patients had ongoing elevation of aminotransferase levels and another 25% showed aminotransferase activity above the so-called healthy range. Several baseline factors were independently associated with post-SVR aminotransferase elevation. Among those, particularly male gender, advanced liver disease and markers for liver steatosis were strongly predictive for persistent ALT elevation. The use of IFN-based antiviral treatment was independently correlated with post-SVR inflammation, further supporting the overall benefit of IFN-free combination regimens. CONCLUSION:This is the first comprehensive study on a large patient cohort investigating the prevalence and risk factors for ongoing liver inflammation after eradication of HCV. Our data show a high proportion of patients with ongoing hepatic inflammation despite HCV eradication with potential implications for the management of approximately one third of all patients upon SVR.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5308806?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0171755
URL الوصول: https://doaj.org/article/4f6785ac49654a088d3cf1a8615adfd1
رقم الأكسشن: edsdoj.4f6785ac49654a088d3cf1a8615adfd1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0171755