دورية أكاديمية
Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis
العنوان: | Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis |
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المؤلفون: | Joon-Hyop Lee, Young Jun Chai, Ka Hee Yi |
المصدر: | Endocrinology and Metabolism, Vol 36, Iss 3, Pp 590-598 (2021) |
بيانات النشر: | Korean Endocrine Society, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
مصطلحات موضوعية: | smoking, thyroid neoplasms, association, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
الوصف: | Background Although smoking is generally carcinogenic, its effect on thyroid cancers is still subject to controversy. The purpose of this study was to summarize the role of smoking in relation to thyroid cancer occurrence. Methods We performed a meta-analysis of 24 eligible studies: 21 case-control studies and three prospective cohort studies. The summary odds ratio (OR) and 95% confidence interval (CI) of all studies were acquired based on random effect model. Further subgroup analyses were conducted according to gender, histological type of thyroid cancer, and smoking status of patients for the case-control studies. Results The summary effect size indicated a negative association of smoking for thyroid cancer (OR, 0.798; 95% CI, 0.681 to 0.935). From the subgroup analyses for the case-control studies, reduced risk of thyroid cancer was observed in both men (OR, 0.734; 95% CI, 0.553 to 0.974) and women (OR, 0.792; 95% CI, 0.700 to 0.897). The protective effect of smoking was observed in studies in which thyroid cancer was limited to differentiated thyroid cancers (DTCs) (OR, 0.798; 95% CI, 0.706 to 0.902). Conclusion Our results suggests that smoking may have a protective effect on thyroid cancer, especially on DTCs. Further studies with larger sample sizes should be conducted in elucidating the dose and time dependent effect of smoking on thyroid cancer with specific focus on the types of thyroid cancers. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English Korean |
تدمد: | 2093-596X 2093-5978 |
Relation: | http://www.e-enm.org/upload/pdf/enm-2021-954.pdf; https://doaj.org/toc/2093-596X; https://doaj.org/toc/2093-5978 |
DOI: | 10.3803/EnM.2021.954 |
URL الوصول: | https://doaj.org/article/4f6e424a831f48e78d21da849c5f2df6 |
رقم الأكسشن: | edsdoj.4f6e424a831f48e78d21da849c5f2df6 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 2093596X 20935978 |
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DOI: | 10.3803/EnM.2021.954 |