دورية أكاديمية
Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors
| العنوان: | Synthesis, Biological Evaluation, and Molecular Docking Studies of Hydrazones as Novel Xanthine Oxidase Inhibitors |
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| المؤلفون: | Ling-Wei Xue, Shi-Tong Li, Yong-Jun Han, Xiao-Qiang Luo |
| المصدر: | Acta Chimica Slovenica, Vol 69, Iss 2, Pp 385-392 (2022) |
| بيانات النشر: | Slovenian Chemical Society, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | hydrazone, xanthine oxidase, inhibition, crystal structure, molecular docking study., Chemistry, QD1-999 |
| الوصف: | A series of hydrazones, 2-cyano-N'-(4-diethylamino-2-hydroxybenzylidene)acetohydrazide (1), N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)-3-chlorobenzohydrazide monohydrate (2·H2O), N'-(2-hydroxy-3-methylbenzylidene)-4-nitrobenzohydrazide (3), and N'-(2-hydroxy-3-trifluoromethoxybenzylidene)-4-nitrobenzohydrazide (4), were prepared and structurally characterized by elemental analysis, IR and 1H NMR spectra, and single crystal X-ray determination. Xanthine oxidase inhibitory activities of the compounds were studied. Among the compounds, 2-cyano-N’-(4-diethylamino-2-hydroxybenzylidene)acetohydrazide shows the most effective activity. Docking simulation was performed to insert the compounds into the crystal structure of xanthine oxidase at the active site to investigate the probable binding modes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1318-0207 1580-3155 |
| Relation: | https://journals.matheo.si/index.php/ACSi/article/view/7252; https://doaj.org/toc/1318-0207; https://doaj.org/toc/1580-3155 |
| DOI: | 10.17344/acsi.2021.7252 |
| URL الوصول: | https://doaj.org/article/4f82800336d747529e40d772e1c8f43a |
| رقم الأكسشن: | edsdoj.4f82800336d747529e40d772e1c8f43a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13180207 15803155 |
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| DOI: | 10.17344/acsi.2021.7252 |