دورية أكاديمية
أعرض في EDS

Oral microbiota study of the patients after hospitalisation for COVID-19, considering selected dental indices and antibiotic therapy using the next generation sequencing method (NGS)

التفاصيل البيبلوغرافية
العنوان: Oral microbiota study of the patients after hospitalisation for COVID-19, considering selected dental indices and antibiotic therapy using the next generation sequencing method (NGS)
المؤلفون: Barbara Brzychczy- Sroka, Katarzyna Talaga-Ćwiertnia, Agnieszka Sroka-Oleksiak, Artur Gurgul, Elżbieta Zarzecka-Francica, Wojciech Ostrowski, Janusz Kąkol, Joanna Zarzecka, Monika Brzychczy-Włoch
المصدر: Journal of Oral Microbiology, Vol 15, Iss 1 (2023)
بيانات النشر: Taylor & Francis Group, 2023.
سنة النشر: 2023
المجموعة: LCC:Infectious and parasitic diseases
LCC:Microbiology
مصطلحات موضوعية: COVID-19, oral microbiota, antibiotic therapy, oral health, next-generation sequencing (NGS), supragingival plaque, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
الوصف: ABSTRACTBackground Poor oral hygiene and the increased incidence and severity of periodontitis may exacerbate SARS-CoV-2 infection. The aim was to evaluate the oral microbiota of 60 participants divided into groups: COVID-19 convalescents who received antibiotics during hospitalization (I), COVID-19 convalescents without antibiotic therapy (II) and healthy individuals (III).Materials and Methods Dental examination was conducted, and oral health status was evaluated using selected dental indexes. Clinical samples (saliva, dorsal swabs, supragingival and subgingival plaque) were collected and used for metagenomic library to the next-generation sequencing (NGS) preparation.Results Each of the clinical materials in particular groups of patients showed a statistically significant and quantitatively different bacterial composition. Patients from group I showed significantly worse oral health, reflected by higher average values of dental indexes and also a higher percentage of Veillonella, Tannerella, Capnocytophaga and Selenomonas genera in comparison to other groups. Additionally, a statistically significant decrease in the amount of Akkermansia type in both groups with COVID-19 was observed for all materials.Conclusions The primary factor affecting the composition of oral microbiota was not the SARS-CoV-2 infection itself, but the use of antibiotic therapy. The increased percentage of pro-inflammatory pathogens observed in COVID-19 patients underscores the importance of preventing periodontal disease and improving oral hygiene in the future.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 20002297
2000-2297
Relation: https://doaj.org/toc/2000-2297
DOI: 10.1080/20002297.2023.2264591
URL الوصول: https://doaj.org/article/4ff37e134f6c470e809cc378e5ca6d4a
رقم الأكسشن: edsdoj.4ff37e134f6c470e809cc378e5ca6d4a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20002297
DOI:10.1080/20002297.2023.2264591