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Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancer

التفاصيل البيبلوغرافية
العنوان: Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancer
المؤلفون: Hsiu-Chuan Chang, Cheng-Chieh Yang, Lai-Keng Loi, Chi-Hsun Hung, Cheng-Hsien Wu, Yu-Cheng Lin
المصدر: Heliyon, Vol 10, Iss 6, Pp e28406- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: OSCC, p62, mTOR, EGFR, Cisplatin resistance, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Cisplatin resistance poses a major challenge in the treatment of oral squamous cell carcinoma (OSCC). Deeper investigations into the mechanisms underlying this drug resistance is of great importance. Here, we used cellular assays and clinical immunohistochemistry to examine molecular pathways involved in both innate and acquired cisplatin resistance. We demonstrated that the p62-mTORC1 signaling complex plays a pivotal role, and is driven by the EGFR signaling network, specifically through the PI3K-Akt axis and the transcription factor C/EBP-β. Elevated p-mTOR expression was associated with cancer relapse and poor prognosis among oral cancer patients. Additionally, we illustrated that mTOR inhibitors enhance the cytotoxic effect of cisplatin, by employing cancer stem cell characteristics. Our work unveils fundamental mechanisms for cisplatin resistance, thereby presenting therapeutic implications for OSCC.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844024044372; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2024.e28406
URL الوصول: https://doaj.org/article/501edcaee715423cb517947ee415e95a
رقم الأكسشن: edsdoj.501edcaee715423cb517947ee415e95a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2024.e28406