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The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula.

التفاصيل البيبلوغرافية
العنوان: The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula.
المؤلفون: Akshaar Brahmbhatt, Evelyn NievesTorres, Binxia Yang, William D Edwards, Prabir Roy Chaudhury, Min Kyun Lee, Hyunjoon Kong, Debabrata Mukhopadhyay, Rajiv Kumar, Sanjay Misra
المصدر: PLoS ONE, Vol 9, Iss 7, p e102542 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Arteriovenous fistulas (AVFs) used for hemodialysis fail because of venous neointimal hyperplasia (VNH). There are 1,500,000 patients that have end stage renal disease worldwide and the majority requires hemodialysis. In the present study, the role of the intermediate early response gene X-1 (IEX-1), also known as IER-3 in the pathogenesis of VNH was evaluated. In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia. In Iex-1-/- mice and wild type (WT) controls, chronic kidney disease was induced and an AVF placed 28 days later by connecting the carotid artery to jugular vein. The outflow vein was removed three days following the creation of the AVF and gene expression analysis demonstrated a significant decrease in vascular endothelial growth factor-A (Vegf-A) and monocyte chemoattractant protein-1 (Mcp-1) gene expression in Iex-1-/- mice when compared to WT mice (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25036043/?tool=EBI; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0102542
URL الوصول: https://doaj.org/article/503f4df8ed4a46798b66a92d8b67fb23
رقم الأكسشن: edsdoj.503f4df8ed4a46798b66a92d8b67fb23
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0102542