دورية أكاديمية
What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?
| العنوان: | What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia? |
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| المؤلفون: | P. Schneider, I. Dubus, F. Gouel, E. Legrand, J. P. Vannier, M. Vasse |
| المصدر: | Advances in Hematology, Vol 2011 (2011) |
| بيانات النشر: | Hindawi Limited, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported increased bone marrow vascularity and elevation of angiogenic cytokines in acute lymphoblastic leukaemia (ALL). VEGF and basic fibroblast growth factor (bFGF) are the major proangiogenic cytokines that have been studied, and evaluation of their prognostic impact in childhood ALL has been reported in several studies, though with controversial results. The antiangiogenic response, contributing to the angiogenic balance, has scarcely been reported. The origin of the factors, their prognostic value, and their relevance as good markers of what really happens in the bone marrow are discussed in this paper. The place of antiangiogenic drugs in ALL has to be defined in the global treatment strategy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-9104 1687-9112 |
| Relation: | https://doaj.org/toc/1687-9104; https://doaj.org/toc/1687-9112 |
| DOI: | 10.1155/2011/274628 |
| URL الوصول: | https://doaj.org/article/50530d64637647418a2fc30fc66e0c4f |
| رقم الأكسشن: | edsdoj.50530d64637647418a2fc30fc66e0c4f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16879104 16879112 |
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| DOI: | 10.1155/2011/274628 |