دورية أكاديمية
Systemic and microvascular comparison of Lactated Ringer’s solution, VIR-HBOC, and alpha-alpha crosslinked haemoglobin-based oxygen carrier in a rat 10% topload model
| العنوان: | Systemic and microvascular comparison of Lactated Ringer’s solution, VIR-HBOC, and alpha-alpha crosslinked haemoglobin-based oxygen carrier in a rat 10% topload model |
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| المؤلفون: | Bjorn K. Song, W. Richard Light, Kim D. Vandegriff, Joe Tucker, William H. Nugent |
| المصدر: | Artificial Cells, Nanomedicine, and Biotechnology, Vol 48, Iss 1, Pp 1079-1088 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Microcirculation, haemoglobin-based oxygen carrier, hyperpolymerized haemoglobin, phosphorescence quenching microscopy, interstitial oxygenation, topload, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Medical support for traumatic haemorrhage is lacking for far-forward combat units. VIR-HBOC (haemoglobin-based oxygen carrier) is a novel biological therapeutic under development as a field-stable resuscitation fluid. HBOCs have a long history of complications, chief among them is vasoconstrictive hypertension, which must be resolved before efficacy testing. As such, VIR-HBOC was compared against Lactated Ringers (LRS; vehicle) and a cross-linked haemoglobin (ααHb; a known vasoactive HBOC) in a rat topload model. Twenty-three male, Sprague Dawley rats were randomly assigned to receive a 10% infusion (estimated total blood volume) of one test article while normotensive and under anaesthesia. Cardiovascular, blood chemistry and oximetry, microvascular arteriolar diameters, and interstitial tissue oxygenation parameters were measured. Circulatory half-life was calculated by plasma total haemoglobin. Treatment with ααHb caused immediate increases in mean arterial pressure compared to LRS and VIR-HBOC groups, and corresponding arteriolar vasoconstriction (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 21691401 2169-141X 2169-1401 |
| Relation: | https://doaj.org/toc/2169-1401; https://doaj.org/toc/2169-141X |
| DOI: | 10.1080/21691401.2020.1809441 |
| URL الوصول: | https://doaj.org/article/508b27af921a48daa076080fed69307e |
| رقم الأكسشن: | edsdoj.508b27af921a48daa076080fed69307e |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 21691401 2169141X |
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| DOI: | 10.1080/21691401.2020.1809441 |