دورية أكاديمية
Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors
| العنوان: | Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors |
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| المؤلفون: | Liron Kogan, David Octeau, Zainab Amajoud, Jeremie Abitbol, Ido Laskov, Alex Ferenczy, Manuela Pelmus, Neta Eisenberg, Roy Kessous, Susie Lau, Amber Yasmeen, Walter H. Gotlieb, Shannon Salvador |
| المصدر: | Gynecologic Oncology Reports, Vol 24, Iss , Pp 43-47 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Gynecology and obstetrics LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Objective: Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC). Methods: Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing. Results: 83 patients with type II endometrial cancer were included in the study, of these, LUSI was diagnosed in 31.3%. During a median follow-up of 45.5 months, patients with LUSI developed more local and distant recurrences (local: 19.2% vs. 3.5%, P = .03; distant: 50% vs. 17.5%, P = .004) and progression events (73.1% vs. 26.3%, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-5789 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352578918300213; https://doaj.org/toc/2352-5789 |
| DOI: | 10.1016/j.gore.2018.03.004 |
| URL الوصول: | https://doaj.org/article/d50bf0e4ec8841db8603d78cbde0eeb8 |
| رقم الأكسشن: | edsdoj.50bf0e4ec8841db8603d78cbde0eeb8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 23525789 |
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| DOI: | 10.1016/j.gore.2018.03.004 |