Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

التفاصيل البيبلوغرافية
العنوان:	Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype
المؤلفون:	Yonghe Wu, Michael Fletcher, Zuguang Gu, Qi Wang, Barbara Costa, Anna Bertoni, Ka-Hou Man, Magdalena Schlotter, Jörg Felsberg, Jasmin Mangei, Martje Barbus, Ann-Christin Gaupel, Wei Wang, Tobias Weiss, Roland Eils, Michael Weller, Haikun Liu, Guido Reifenberger, Andrey Korshunov, Peter Angel, Peter Lichter, Carl Herrmann, Bernhard Radlwimmer
المصدر:	Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
بيانات النشر:	Nature Portfolio, 2020.
سنة النشر:	2020
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Glioblastoma is divided into four subtypes based on molecular profiling at the methylome and transcriptome level. Here the authors perform an integrative analysis of these subtypes resulting in the identification of SOX10 whose loss induces a mesenchymal phenotype and promotes tumour progression.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-020-20225-w
URL الوصول:	https://doaj.org/article/50c3ca33473a428aa36c9a52cf6638ef
رقم الأكسشن:	edsdoj.50c3ca33473a428aa36c9a52cf6638ef
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-020-20225-w