دورية أكاديمية
Hyperglycemia-stimulating diet induces liver steatosis in sheep
| العنوان: | Hyperglycemia-stimulating diet induces liver steatosis in sheep |
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| المؤلفون: | Mugagga Kalyesubula, Ramgopal Mopuri, Alexander Rosov, Tamir Alon, Nir Edery, Uzi Moallem, Hay Dvir |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) |
| بيانات النشر: | Nature Portfolio, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Hepatic steatosis is strongly associated with chronic liver disease and systemic metabolic disorder. Adipose lipolysis is a recognized principal source of intrahepatic fat in various metabolic disorders, including non-alcoholic fatty liver disease. We hypothesized that, in the premorbid state, hepatic de novo lipogenesis (DNL) driven by excess carbohydrates abundance might play a more significant role. We employed a novel nutritional model in sheep of two distinct carbohydrates abundances. During 4 months of the dietary treatment, lambs were monitored for metabolic and terminal liver parameters. Lambs grown on the high-calorie (HC) diet were consistently more hyperglycemic and hyperinsulinemic than lambs grown on the lower-calorie (LC) diet (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-020-68909-z |
| URL الوصول: | https://doaj.org/article/50c5163424224121a15cac57f3cef2f1 |
| رقم الأكسشن: | edsdoj.50c5163424224121a15cac57f3cef2f1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-020-68909-z |