دورية أكاديمية
A Predictive Model for Graft Failure in Femtosecond Laser-Assisted Penetrating Keratoplasty Among Chinese Patients: A 2-Year Study
| العنوان: | A Predictive Model for Graft Failure in Femtosecond Laser-Assisted Penetrating Keratoplasty Among Chinese Patients: A 2-Year Study |
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| المؤلفون: | Junxin Ma, Xueqian Cao, Yang Liu, Jin Huang, Yuting Gong, Xinyu Pan, Zhongguo Li, Linnong Wang |
| المصدر: | Ophthalmology and Therapy, Vol 13, Iss 7, Pp 2037-2053 (2024) |
| بيانات النشر: | Adis, Springer Healthcare, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | Predictive model, Femtosecond laser-assisted penetrating keratoplasty, Graft failure, Chinese patients, Ophthalmology, RE1-994 |
| الوصف: | Abstract Introduction Graft failure is a major challenge in femtosecond laser-assisted penetrating keratoplasty (Fs-PKP). This study focuses on the development and validation of a clinical predictive model aimed at identifying the risk of graft failure in individuals undergoing Fs-PKP in China, offering a tailored approach to improve surgical outcomes. Methods This retrospective cohort study at Nanjing First Hospital involved 238 patients and followed the TRIPOD statement. The cohort was divided into a training set (n = 166) and a validation set (n = 72) in a 7:3 ratio. It analyzed 23 predictor variables related to recipient, donor, and surgical factors, defining graft failure as “visually significant and irreversible corneal stromal edema, haze, or scarring.” A comprehensive nomogram was created using univariate and multivariate Cox regression analyses and assessed by concordance index (C-index), time-dependent receiver operating characteristics (ROC) curve, calibration plots, and decision curve analysis (DCA). Results Five critical risk factors were identified: recipients’ history of systemic autoimmune disorders, ocular trauma, prior penetrating keratoplasty (PKP) history, donors’ diabetes history, and the endothelial cell density of the donor cornea. The nomogram showed a C-index of 0.72 (95% CI 0.65–0.79) in the training group and 0.66 (95% CI 0.55–0.76) in the validation group, indicating robust predictive accuracy. Time-dependent ROC curves, calibration plots, and DCA consistently validated the model’s reliability, predictive power, and clinical utility across both training and validation cohorts. Conclusions Our study developed and validated a model incorporating five key factors, enhancing preoperative prediction and management for Chinese patients with Fs-PKP graft failure. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2193-8245 2193-6528 |
| Relation: | https://doaj.org/toc/2193-8245; https://doaj.org/toc/2193-6528 |
| DOI: | 10.1007/s40123-024-00955-6 |
| URL الوصول: | https://doaj.org/article/50c9bb284477495e83bfc621fceb8d00 |
| رقم الأكسشن: | edsdoj.50c9bb284477495e83bfc621fceb8d00 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 21938245 21936528 |
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| DOI: | 10.1007/s40123-024-00955-6 |