دورية أكاديمية
أعرض في EDS

Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion

التفاصيل البيبلوغرافية
العنوان: Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion
المؤلفون: Xiaodong Yang, Ilango Balakrishnan, Beverly Torok-Storb, Manoj M. Pillai
المصدر: Advances in Hematology, Vol 2012 (2012)
بيانات النشر: Hindawi Limited, 2012.
سنة النشر: 2012
المجموعة: LCC:Diseases of the blood and blood-forming organs
مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: Marrow stromal cells (MSCs, also termed mesenchymal stem cells) have been proposed as a promising cellular therapy for tissue injury including radiation-induced marrow failure, but evidence for a direct effect is lacking. To assess the effects of MSCs on survival after lethal irradiation, we infused syngeneic MSCs (either as immortalized MSCs clones or primary MSCs) intravenously into wild-type C57/Bl6 mice within 24 hours of lethal total body irradiation (TBI). Mice receiving either of the MSC preparations had significantly improved survival when compared to controls. In vivo imaging, immune histochemistry, and RT-PCR employed to detect MSCs indicated that the infused MSCs were predominantly localized to the lungs and rapidly cleared following infusion. Our results suggest that a single infusion of MSCs can improve survival after otherwise lethal TBI but the effect is not due to a direct interaction with, or contribution to, the damaged marrow by MSCs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-9104
1687-9112
Relation: https://doaj.org/toc/1687-9104; https://doaj.org/toc/1687-9112
DOI: 10.1155/2012/142530
URL الوصول: https://doaj.org/article/50d4559cf5c8465a8b58d1bd529d9caf
رقم الأكسشن: edsdoj.50d4559cf5c8465a8b58d1bd529d9caf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16879104
16879112
DOI:10.1155/2012/142530