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Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus.

التفاصيل البيبلوغرافية
العنوان: Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus.
المؤلفون: Marina Ben Shimon, Talya Zeimer, Efrat Shavit Stein, Avital Artan-Furman, Sagi Harnof, Joab Chapman, Arik Eisenkraft, Chaim G Pick, Nicola Maggio
المصدر: PLoS ONE, Vol 12, Iss 11, p e0188524 (2017)
بيانات النشر: Public Library of Science (PLoS), 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Transient amnesia is a common consequence of minimal traumatic brain injury (mTBI). However, while recent findings have addressed the mechanisms involved in its onset, the processes contributing to its recovery have not yet been addressed. Recently, we have found that thrombin is detected at high concentrations in the brain of mice after exposure to mTBI and that in such settings amnesia is rescued by either inhibiting thrombin activity or by blockade of PAR1. Here, we report that mice spontaneously recover from amnesia after two weeks from mTBI exposure. At this time point, long term potentiation was equally evoked in injured vs. control animals with thrombin concentration in the brain being normalized at this stage. These findings, which refer to the specific aspect of memory retrieval upon mTBI, together with our previous work, hint to a strong correlation between cognitive defects in the context of mTBI and thrombin concentrations in the brain. This may suggest that a possible scavenging of thrombin in the brain at early phases following mTBI may improve memory function.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5705129?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0188524
URL الوصول: https://doaj.org/article/50f2f2c2e2764a6284bf5c08012ed4b3
رقم الأكسشن: edsdoj.50f2f2c2e2764a6284bf5c08012ed4b3
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0188524