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Alleviating Effect of a Magnetite (Fe3O4) Nanogel against Waterborne-Lead-Induced Physiological Disturbances, Histopathological Changes, and Lead Bioaccumulation in African Catfish

التفاصيل البيبلوغرافية
العنوان: Alleviating Effect of a Magnetite (Fe3O4) Nanogel against Waterborne-Lead-Induced Physiological Disturbances, Histopathological Changes, and Lead Bioaccumulation in African Catfish
المؤلفون: Afaf N. Abdel Rahman, Basma Ahmed Elkhadrawy, Abdallah Tageldein Mansour, Heba M. Abdel-Ghany, Engy Mohamed Mohamed Yassin, Asmaa Elsayyad, Khairiah Mubarak Alwutayd, Sameh H. Ismail, Heba H. Mahboub
المصدر: Gels, Vol 9, Iss 8, p 641 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Science
LCC:Chemistry
LCC:Inorganic chemistry
LCC:General. Including alchemy
مصطلحات موضوعية: Clarias gariepinus, health status, lead toxicity, magnetite nanogel, nanotechnology, tissue architecture, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65
الوصف: Heavy metal toxicity is an important issue owing to its harmful influence on fish. Hence, this study is a pioneer attempt to verify the in vitro and in vivo efficacy of a magnetite (Fe3O4) nanogel (MNG) in mitigating waterborne lead (Pb) toxicity in African catfish. Fish (n = 160) were assigned into four groups for 45 days. The first (control) and second (MNG) groups were exposed to 0 and 1.2 mg L−1 of MNG in water. The third (Pb) and fourth (MNG + Pb) groups were exposed to 0 and 1.2 mg L−1 of MNG in water and 69.30 mg L−1 of Pb. In vitro, the MNG caused a dramatic drop in the Pb level within 120 h. The Pb-exposed group showed the lowest survival (57.5%) among the groups, with substantial elevations in hepato-renal function and lipid peroxide (MDA). Moreover, Pb exposure caused a remarkable decline in the protein-immune parameters and hepatic antioxidants, along with higher Pb residual deposition in muscles and obvious histopathological changes in the liver and kidney. Interestingly, adding aqueous MNG to Pb-exposed fish relieved these alterations and increased survivability. Thus, MNG is a novel antitoxic agent against Pb toxicity to maintain the health of C. gariepinus.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2310-2861
Relation: https://www.mdpi.com/2310-2861/9/8/641; https://doaj.org/toc/2310-2861
DOI: 10.3390/gels9080641
URL الوصول: https://doaj.org/article/513b7b571a574736956d6ee898835c95
رقم الأكسشن: edsdoj.513b7b571a574736956d6ee898835c95
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23102861
DOI:10.3390/gels9080641